Publications

Publications

2020

Štěpán Kouřil, Julie de Sousa, Jan Václavík, David Friedecký and Tomáš Adam. CROP: Correlation-based reduction of feature multiplicities in untargeted metabolomic data. Bioinformatics, 2020, accepted.

Julie de Sousa, Ondřej Vencálek, Karel Hron, Jan Václavík, David Friedecký, Tomáš Adam. Bayesian multiple hypotheses testing in compositional analysis of untargeted metabolomic data. Analytica Chimica Acta Volume 1097, 8 February 2020, Pages 49-61. DOI: 10.1016/j.aca.2019.11.006


2019

Walach, J; Filzmoser, P; Kouril, S; Friedecky, D; Adam, T. Cellwise outlier detection and biomarker identification in metabolomics based on pairwise log ratios. JOURNAL OF CHEMOMETRICS Article Number: e3182 DOI: 10.1002/cem.3182 Early Access Date: DEC 2019

Jáčová J, Jořenek M, Pospíšková K, Najdekr L, Zajoncová L, Friedecký D, Adam T. Urease-immobilized magnetic microparticles in urine sample preparation for metabolomic analysis by gas chromatography-mass spectrometry. J Chromatogr A. 2019 Nov 8;1605:360355. doi: 10.1016/j.chroma.2019.07.009. Epub 2019 Jul 10.

David J, Chrastina P, Pešková K, Kožich V, Friedecký D, Adam T, Hlídková E, Vinohradská H, Novotná D, Hedelová M, Al Taji E, Holubová A, Skalická V, Macek M, Gaillyová R, Votava F. Epidemiology of rare diseases detected by newborn screening in the Czech Republic. Cent Eur J Public Health. 2019 Jun;27(2):153-159. doi: 10.21101/cejph.a5441.

Slavik L, Jacova J, Friedecky D, Ulehlova J, Tauber Z, Prochazkova J, Hlusi A, Palova M. Evaluation of the DOAC-Stop Procedure by LC-MS/MS Assays for Determining the Residual Activity of Dabigatran, Rivaroxaban, and Apixaban. Clin Appl Thromb Hemost. 2019 Jan-Dec;25:1076029619872556. doi: 10.1177/1076029619872556.

Hoevenaars FPM, Keijer J, van der Stelt I, et al. White Adipose Tissue Response of Obese Mice to Ambient Oxygen Restriction at Thermoneutrality: Response Markers Identified, but no WAT Inflammation. Genes (Basel). 2019;10(5). doi:10.3390/genes10050359

Jacova J, Gardlo A, Dimandja J-MD, Adam T, Friedecky D. Impact of sample dimensionality on orthogonality metrics in comprehensive two-dimensional separations. Anal Chim Acta. 2019;1064:138-149. doi:10.1016/j.aca.2019.03.018


2018

Mádrová L, Krijt M, Barešová V, et al. Mass spectrometric analysis of purine de novo biosynthesis intermediates. PLoS One. 2018;13(12):e0208947. doi:10.1371/journal.pone.0208947

Camateros P, Kanagaratham C, Najdekr L, et al. Toll-like receptor 7/8 Ligand, S28463, suppresses ascaris suum–induced allergic asthma in nonhuman primates. Am J Respir Cell Mol Biol. 2018;58(1):55-65. doi:10.1165/rcmb.2017-0184OC

Salovska B, Janeckova H, Fabrik I, et al. Radio-Sensitizing Effects of VE-821 and beyond: Distinct Phosphoproteomic and Metabolomic Changes after ATR Inhibition in Irradiated MOLT-4 Cells. Vol 13.; 2018. doi:10.1371/journal.pone.0199349

Kučera J, Spáčil Z, Friedecký D, Novák J, Pekař M, Bienertová-Vašků J. Human White Adipose Tissue Metabolome: Current Perspective. Obesity. 2018;26(12):1870-1878. doi:10.1002/oby.22336

Karlíková R, Široká J, Mech M, et al. Newborn foal with atypical myopathy. J Vet Intern Med. 2018;32(5):1768-1772. doi:10.1111/jvim.15236

Slavik L, Lukes J, Friedecky D, et al. Multianalyte Determination of NOACs Using LC-MS/MS and Comparison with Functional Coagulation Assays. Clin Lab. 2018;64(10/2018):1611-1621. doi:10.7754/Clin.Lab.2018.180335

Václavík J, Coene KLM, Vrobel I, et al. Structural elucidation of novel biomarkers of known metabolic disorders based on multistage fragmentation mass spectra. J Inherit Metab Dis. 2018;41(3):407-414. doi:10.1007/s10545-017-0109-4


2017

Mičová K, Friedecký D, Adam T. Mass Spectrometry for the Sensitive Analysis of Intracellular Nucleotides and Analogues. In: Mass Spectrometry. InTech; 2017. doi:10.5772/68073

Karlíková R, Mičová K, Najdekr L, et al. Metabolic status of CSF distinguishes rats with tauopathy from controls. Alzheimer’s Res Ther. 2017;9(1):1-16. doi:10.1186/s13195-017-0303-5

Vrobel I, Friedecký D, Faber E, et al. Novel sulphur-containing imatinib metabolites found by untargeted LC-HRMS analysis. Eur J Pharm Sci. 2017;104(February):335-343. doi:10.1016/j.ejps.2017.04.014

Jáčová J, Gardlo A, Friedecký D, Adam T, Dimandja J-MD. Sample-independent approach to normalize two-dimensional data for orthogonality evaluation using whole separation space scaling. J Chromatogr A. 2017;1511:1-8. doi:10.1016/j.chroma.2017.06.076

van der Stelt I, Hoevenaars F, Široká J, et al. Metabolic Response of Visceral White Adipose Tissue of Obese Mice Exposed for 5 Days to Human Room Temperature Compared to Mouse Thermoneutrality. Front Physiol. 2017;8:179. doi:10.3389/fphys.2017.00179


2016

Zezulová M, Bartoušková M, Hlídková E, et al. Citrulline as a biomarker of gastrointestinal toxicity in patients with rectal carcinoma treated with chemoradiation. Clin Chem Lab Med. 2016;54(2):305-314. doi:10.1515/cclm-2015-0326

Faber E, Divoká M, Skoumalová I, et al. A lower dosage of imatinib is sufficient to maintain undetectable disease in patients with chronic myeloid leukemia with long-term low-grade toxicity of the treatment. Leuk Lymphoma. 2016;57(2):370-375. doi:10.3109/10428194.2015.1056184

Karlíková R, Široká J, Friedecký D, et al. Metabolite Profiling of the Plasma and Leukocytes of Chronic Myeloid Leukemia Patients. J Proteome Res. 2016;15(9):3158-3166. doi:10.1021/acs.jproteome.6b00356

Gardlo A, Smilde AK, Hron K, et al. Normalization techniques for PARAFAC modeling of urine metabolomic data. Metabolomics. 2016;12(7):117. doi:10.1007/s11306-016-1059-9

Najdekr L, Friedecký D, Tautenhahn R, et al. Influence of Mass Resolving Power in Orbital Ion-Trap Mass Spectrometry-Based Metabolomics. Anal Chem. 2016;88(23):11429-11435. doi:10.1021/acs.analchem.6b02319

Karlíková R, Široká J, Jahn P, et al. Equine atypical myopathy: A metabolic study. Vet J. 2016;216:125-132. doi:10.1016/j.tvjl.2016.07.015

Vrobel I, Janečková H, Faber E, et al. Ultrafast Online SPE-MS/MS Method for Quantification of 3 Tyrosine Kinase Inhibitors in Human Plasma. Ther Drug Monit. 2016;38(4):516-524. doi:10.1097/FTD.0000000000000309

Ligasová A, Liboska R, Friedecký D, et al. Dr Jekyll and Mr Hyde: a strange case of 5-ethynyl-2’-deoxyuridine and 5-ethynyl-2’-deoxycytidine. Open Biol. 2016;6(1):150172. doi:10.1098/rsob.150172


1998 – 2015

Ligasová A, Strunin D, Friedecký D, Adam T, Koberna K. A fatal combination: a thymidylate synthase inhibitor with DNA damaging activity. PLoS One. 2015;10(2):1-21. doi:10.1371/journal.pone.0117459

Janeckova H, Kalivodova A, Najdekr L, et al. Untargeted metabolomic analysis of urine samples in the diagnosis of some inherited metabolic disorders. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015;159(4):582-585. doi:10.5507/bp.2014.048

Friedecký D, Mičová K, Faber E, Hrdá M, Široká J, Adam T. Detailed study of imatinib metabolization using high-resolution mass spectrometry. J Chromatogr A. 2015;1409:173-181. doi:10.1016/j.chroma.2015.07.033

Najdekr L, Gardlo A, Mádrová L, et al. Oxidized phosphatidylcholines suggest oxidative stress in patients with medium-chain acyl-CoA dehydrogenase deficiency. Talanta. 2015;139:62-66. doi:10.1016/j.talanta.2015.02.041

Votava F, Kožich V, Chrastina P, et al. The results of expanded newborn screening in the Czech Republic. Ces Pediatr. 2014;69(2).

Kanagaratham C, Kalivodová A, Najdekr L, et al. Fenretinide prevents inflammation and airway hyperresponsiveness in a mouse model of allergic asthma. Am J Respir Cell Mol Biol. 2014;51(6):783-792. doi:10.1165/rcmb.2014-0121OC

Wojtowicz P, Janečková H, Friedecký D, Adam T. Metabolomic techniques in biomedicine. Chem List. 2013;107(1).

Rohon P, Faber E, Divoka M, et al. A significant proportion of patients with chronic myeloid leukemia and suboptimal response according to European Leukemia Net criteria have excellent prognosis without treatment change. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2013;157(2):181-188. doi:10.5507/bp.2011.059

Wojtowicz P, Janečková H, Friedecký D, Adam T. TECHNIKY METABOLOMIKY V BIOMEDICÍNĚ. Chem Pap. 2013;11.

Janečková H, Wojtowicz P, Hron K, Friedecký D, Adam T. Untargeted metabolomic analysis of dry blood spots for diagnosing inherited metabolic disorders. Klin Biochem a Metab. 2012;20(3).

Mičová K, Friedecký D, Faber E, Adam T. Routine therapeutic monitoring of tyrosin kinase inhibitors by LCMS/MS. Klin Biochem a Metab. 2012;20(4).

Friedecký D, Lemr K. Mass spectrometry – Source of analytical information. Klin Biochem a Metab. 2012;20(4).

Friedecký D, Lemr K. Introduction to mass spectrometry. Klin Biochem a Metab. 2012;20(3).

Cizkova M, Bouchalova K, Friedecky D, et al. High lapatinib plasma levels in breast cancer patients: risk or benefit? Tumori. 2012;98(1):162-165. doi:10.1700/1053.11516

Mičová K, Friedecký D, Faber E, Adam T. Isotope dilution direct injection mass spectrometry method for determination of four tyrosine kinase inhibitors in human plasma. Talanta. 2012;93:307-313. doi:10.1016/j.talanta.2012.02.038

Janečková H, Hron K, Wojtowicz P, et al. Targeted metabolomic analysis of plasma samples for the diagnosis of inherited metabolic disorders. J Chromatogr A. 2012;1226:11-17. doi:10.1016/j.chroma.2011.09.074

Faber E, Friedecký D, Mičová K, et al. Imatinib trough plasma levels do not correlate with the response to therapy in patients with chronic myeloid leukemia in routine clinical setting. Ann Hematol. 2012;91(6):923-929. doi:10.1007/s00277-011-1394-x

Béres T, Gemrotová M, Tarkowski P, et al. Analysis of cytokinin nucleotides by capillary zone electrophoresis with diode array and mass spectrometric detection in a recombinant enzyme in vitro reaction. Anal Chim Acta. 2012;751(null):176-181. doi:10.1016/j.aca.2012.08.049

Barešová A, Friedecký D, Adam T. Analysis of nucleotides in dry blood spots. Chem List. 2011;105(3).

Mičová K, Friedecký D, Polýnková A, Faber E, Adam T. Determination of tyrosine kinase inhibitors in human plasma by UHPLC-MS/MS. Chem List. 2010;104(13).

Zídková L, Krijt J, Sládková J, et al. Oligodendroglia from ADSL-deficient patient produce SAICAribotide and SAMP. Mol Genet Metab. 2010;101(2-3):286-288. doi:10.1016/j.ymgme.2010.06.014

Mičová K, Friedecký D, Faber E, Polýnková A, Adam T. Flow injection analysis vs. ultra high performance liquid chromatography coupled with tandem mass spectrometry for determination of imatinib in human plasma. Clin Chim Acta. 2010;411(23-24):1957-1962. doi:10.1016/j.cca.2010.08.014

Faber E, Friedecký D, Micová K, et al. Imatinib dose escalation in two patients with chronic myeloid leukemia, with low trough imatinib plasma levels measured at various intervals from the beginning of therapy and with suboptimal treatment response, leads to the achievement of higher plasma le. Int J Hematol. 2010;91(5):897-902. doi:10.1007/s12185-010-0576-y

Votava F, Kožich V, Šťastná S. Novorozenecký screening v České republice. Postgraduální medicína. 2010;12(7):785-792.

Mičová K, Friedecký D, Polýnková A, Faber E, Adam T. STANOVENÍ HLADINY TYROSINKINASOVÝCH INHIBITOR Ů METODOU UHPLC-MS / MS. Chem Pap. 2010;34:31-34.

Bouchalova K, Cizkova M, Cwiertka K, Trojanec R, Friedecky D, Hajduch M. Lapatinib in breast cancer – the predictive significance of HER1 (EGFR), HER2, PTEN and PIK3CA genes and lapatinib plasma level assessment. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2010;154(4):281-288. http://www.ncbi.nlm.nih.gov/pubmed/21293538.

Tomkova J, Friedecky D, Polynkova A, Adam T. Capillary electrophoresis determination of thiopurine methyl transferase activity in erythrocytes. J Chromatogr B Analyt Technol Biomed Life Sci. 2009;877(20-21):1943-1945. doi:10.1016/j.jchromb.2009.05.005

Mičová K, Friedecký D, Faber E, Adam T. Stanovení hladin imatinibu pomocí kapilární elektroforézy u pacient ů s chronickou myeloidní leukémií k. Chem Pap. 2009;188:185-188.

Tomkova J, Friedecky D, Vyskocilova P, Adam T. ITPase activity in dry blood spots is comparable with that in fresh erythrocytes. Nucleosides Nucleotides Nucleic Acids. 2008;27(6):656-660. doi:10.1080/15257770802143897

Friedecký D, Vyskočilová P, Fryčák P, Hornik P, Lemr K, Adam T. Mass-spectrometric properties of imidazol ribosides. Klin Biochem a Metab. 2007;15(4).

Vyskočilová P, Kuchyňová H, Opluštilová L, et al. Analysis of erythrocytes in the diagnostics of PDNS defects. Klin Biochem a Metab. 2007;15(4).

Vyskočilova P, Hornik P, Friedecký D, Adam T. Spectral and electromigration characteristics of imidazole ribosides. Chem List. 2007;101(3).

Friedecký D, Tomková J, Maier V, Janost’áková A, Procházka M, Adam T. Capillary electrophoretic method for nucleotide analysis in cells: application on inherited metabolic disorders. Electrophoresis. 2007;28(3):373-380. doi:10.1002/elps.200600262

Friedecky D, Tomkova J, Adam T. Determination of ITPase Activity by Capillary Electrophoresis. Clin Chem. 2007;53(6):1162-1164. doi:10.1373/clinchem.2006.081307

Hornik P, Vyskocilová P, Friedecký D, Janostáková A, Adamová K, Adam T. Analysis of aminoimidazole ribosides by capillary electrophoresis–diagnosing defects in second part of purine biosynthetic pathway. Clin Chim Acta. 2007;376(1-2):184-189. doi:10.1016/j.cca.2006.08.020

Vyskočilová P, Kuchyňová H, Opluštilová L, et al. Analýza erytrocytů v diagnostice defektů PDNS. Klin Biochem a Metab. 2007;15(4):222-224.

Vyskočilová P, Hornik P, Friedecký D, Adam T. UV spektrální a elektromigrační charakteristiky imidazolových ribosidů. Chem Pap. 2007;101.

Friedecký D, Vyskočilová P, Fryčák P, et al. Hmotově-spektrometrické vlastnosti imidazolových ribosidů. Klin Biochem a Metab. 2007;15(4):212-214.

Faber E, Friedecký D. Význam monitorování plazmatických koncentrací imatinibu pro úspěšnost cílené léčby nemocných s chrnoickou myeloidní leukémií. Farmakoterapie. 2007;5:6-7.

Friedecký D, Calábková R, Bar J, Novotný D, Schneiderka P. Srovnání metod pro stanovení hladiny kreatininu v séru. FONS. 2007:16-18.

Friedecký D, Hlídková E, Novotný D, Schneiderka P. Kreatinin – biochemie, meabolismus a dědičné metabolické porcuhy. FONS. 2007:23-25.

Friedecký D, Hušková R, Chrastina P, Adam PHT. Kreatinin – srovnání metod pro stanovení hladiny v moči. FONS. 2007:16-21.

Vyskočilová P, Hornik P, Friedecký D, Fryčák P, Lemr K, Adam T. Synthesis and mass spectrometric fragmentation characteristics of imidazole ribosides-analogs of intermediates of purine de novo synthetic pathway. Nucleosides, Nucleotides and Nucleic Acids. 2006;25(9-11). doi:10.1080/15257770600894691

Friedecký D, Bednář P, Procházka M, Adam T. Analysis of intracellular nucleotides by capilary electrophoresis-mass spectrometry. Nucleosides, Nucleotides and Nucleic Acids. 2006;25(9-11). doi:10.1080/15257770600894667

Hornik P, Vyskocilová P, Friedecký D, Adam T. Diagnosing AICA-ribosiduria by capillary electrophoresis. J Chromatogr B Analyt Technol Biomed Life Sci. 2006;843(1):15-19. doi:10.1016/j.jchromb.2006.05.020

Gaudinová A, Dobrev PI, Šolcová B, et al. The Involvement of Cytokinin Oxidase/Dehydrogenase and Zeatin Reductase in Regulation of Cytokinin Levels in Pea (Pisum sativum L.) Leaves. J Plant Growth Regul. 2005;24(3):188-200. doi:10.1007/s00344-005-0043-9

Friedecký D, Vyskočilová P, Kuchyňová H, Hornik P, Adam T. Nucleotides in Erythrocytes – Incorporation Study *. Klin Biochem a Metab. 2005;13(4):182-183.

Huskova R, Bartak P, Ap L, Friedecky D, Adam T. Analytical derivatization–a tool for determination of orotic acid. J Chromatogr B. 2004;799(2):303-309. doi:10.1016/j.jchromb.2003.10.068

Lochman P, Adam TT, Friedecký D, Hlídková E, Škopková Z, Skopková Z. High-throughput capillary electrophoretic method for determination of total aminothiols in plasma and urine. Electrophoresis. 2003;24(78):1200-1207. doi:10.1002/elps.200390154

Friedecký D, Adam TT, Barták P. Capillary electrophoresis for detection of inherited disorders of purine and pyrimidine metabolism: A selective approach. Electrophoresis. 2002;23(4):565-571. doi:10.1002/1522-2683(200202)23:4<565::AID-ELPS565>3.0.CO;2-S

Adam T, Lochman P, Friedecký D. Screening method for inherited disorders of purine and pyrimidine metabolism by capillary electrophoresis with reversed electroosmotic flow. J Chromatogr B Analyt Technol Biomed Life Sci. 2002;767(2):333-340. http://www.ncbi.nlm.nih.gov/pubmed/11885862.

Barták P, Bednár P, Friedecký D, Haviger a, Sevcík J. Fast analysis of antibacterial isothiazolones by capillary electrophoresis. J Chromatogr B Biomed Sci Appl. 2001;758(2):323-325. http://www.ncbi.nlm.nih.gov/pubmed/11486844.

Lemr K, Adam T, Frycák P, Friedecký D. Mass spectrometry for analysis of purine and pyrimidine compounds. Adv Exp Med Biol. 2000;486.

Friedecký D, Adam T, Ševčík J, Barták P. New techniques in diagnostics by capillary electrophoresis of hereditary disorders of purine and pyrimidine metabolism. Chem List. 1999;93(8).

Barták P, Sevcık J, Adam T, Friedecky D, Lemr K, Stránský Z. Study of cytokinin separation using capillary electrophoresis with cyclodextrin additives. J Chromatogr A. 1998;818:231-238.

Lemr K, Adam T, Frycák P, Friedecký D. Mass Spectrometry for Analysis of Purine and Pyrimidine Compounds. Purine Pyrimidine Metab Man X. doi:10.1007/0-306-46843-3_76